Optimized MALDI-TOF MS Strategy for Characterizing Polymers

Characterizing synthetic polymers by MALDI MS.

Different polymer formulations possess unique chemical, physical, and mechanical properties. Small variations in the structure of a given polymer formulation can significantly change its characteristics, resulting in new functions and applications. For example, polyvinyl alcohol is a water-soluble synthetic polymer made by alcoholysis of polyvinyl acetate. Its chemical and physical properties d...

MALDI-TOF MS in Prenatal Genomics.

Prenatal diagnosis aims either to provide the reassurance to the couples at risk of having an affected child by timely appropriate therapy or to give the parents a chance to decide the fate of the unborn babies with health problems. Invasive prenatal diagnosis (IPD) is accurate, however, carrying a risk of miscarriage. Non-invasive prenatal diagnosis (NIPD) has been developed based on the exist...

Dossier MALDI - TOF ■ Oligonucleotide analysis by MALDI - MS

Matrix-assisted laser desorption (MALDI) time-offlight (TOF) mass spectrometry (MS) has been successfully used for oligonucleotide sequence confirmation by mass analysis of fragments generated by concentration-dependent exonuclease digestion. This approach is particularly well-suited to the analysis of synthetic DNA due to the relatively short length of the DNA strands. Additionally, an importa...

Kallow et al: MALDI-TOF MS for Microbial Identification

Immediately after the first MALDI-TOF instrument became available, microbiologists have been investigating its potential as a platform for high throughput identification of microorganisms. A remarkable finding very early in these investigations was that despite the dynamic nature of the bacterial cell, components of the mass spectral profile were sufficiently stable and remained unchanged in sp...

Characterization of fengycin homologues produced by Bacillus subtilis K1 by MALDI-TOF tandem mass spectrometry (MALDI TOF MS/MS)